John A. Gray, M.D., Ph.D.

Resident Psychiatrist - PGY3
University of California San Francisco
jgraymdphd@gmail.com



My PhD dissertation, successfully defended March 18th, 2003

"Regulation of 5-HT2A Serotonin Receptors by Arrestins"
Download as Adobe Acrobat .pdf (5.71MB): dissertation.pdf



Educational Background:

2006-2009 – Residency in Psychiatry, University of California, San Francisco
1997-2005 – M.D., Case Western Reserve University School of Medicine
1999-2003 – Ph.D. in Biochemistry, Case Western Reserve University
1993-1997 – B.S. in Biochemistry, Case Western Reserve University, summa cum laude


Professional Experience:

2007-current – Postdoctoral Research
                       Department of Neuroscience, University of California, San Francisco
                       Mentor: Roger Nicoll, MD, Professor, Cellular and Molecular Pharmacology

1999-2003   –  Ph.D. Dissertation Research
                       Department of Biochemistry, Case Western Reserve University
                       Advisor: Bryan Roth, MD PhD, Professor of Biochemistry and Neuroscience

Summer 1996– Stanley Scholar and Research Assistant
                       Department of Psychiatry, University Hospitals of Cleveland
                       Mentors: Peter F. Buckley, M.D., Professor of Psychiatry
                                     S. Charles Schulz, M.D., Chair, Department of Psychiatry


Fellowships and Awards:

2007 – NIMH Outstanding Resident Award in Psychiatric Research
2003 – Invited Student Speaker – CWRU Graduate Student Symposium
1997 – 2005 – Medical Scientist Training Program (MSTP) fellowship
1997 – Induction into Phi Beta Kappa Honor Society
1997 – Undergraduate Research Award – CWRU Psychiatry Research Day


Publications:

Gray JA and Roth BL (2007). The pipeline and future of drug development in schizophrenia. Molecular Psychiatry, 12(10): 904-922.

Gray JA and Roth BL (2007). Molecular targets for treating cognitive dysfunction in schizophrenia. Schizophrenia Bulletin, 33(5): 1100-1119.

Gray JA and Roth BL (2006). Developing selectively non-selective drugs for treating CNS disorders. Drug Discovery Today: Therapeutic Strategies, 3(4): 413-419.

Xia Z, Hufeisen SJ, Gray JA, and Roth BL (2003). The PDZ-binding domain is essential for the dendritic targeting of 5-HT2A serotonin receptors in cortical pyramidal neurons in vitro. Neuroscience, 122(4): 907-920. Download PDF (1.17MB)

Gray JA, Compton-Toth BA, and Roth BL (2003). Identification of two serine residues essential for agonist-induced 5-HT2A receptor desensitization. Biochemistry, 42(36): 10853-10862. Download PDF (293K)

Xia Z, Gray JA, Compton-Toth BA, and Roth BL (2003). A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction. J Biol Chem, 278(24): 21901-21908. Download PDF (478K)

Gray JA, Bhatnagar A, Gurevich VV, and Roth BL (2003). The interaction of a constitutively active arrestin with the arrestin-insensitive 5-HT2A receptor induces agonist-independent internalization. Mol Pharmacol, 63(5): 961-972. Download PDF (638K)

Gray JA and Roth BL (2002). A Last GASP for GPCRs? Science, 297: 529-531. Download PDF (283K)

Gray JA and Roth BL (2001). Paradoxical trafficking and regulation of 5-HT2A receptors by agonists and antagonists. Brain Res Bull, 56(5): 441-451. Download PDF (308K)

Gray JA, Sheffler DJ, Bhatnagar A, Woods JA, Hufeisen SJ, Benovic JL, and Roth BL (2001). Cell-type specific effects of endocytosis inhibitors on 5-HT2A receptor desensitization and resensitization reveal an arrestin-, GRK2- and GRK5-independent mode of regulation in HEK-293 cells. Mol Pharmacol 60(5): 1020-1030. Download PDF (377K)

Bhatnagar A, Willins DL, Gray JA, Woods JA, Benovic JL, and Roth BL (2001). The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis. J Biol Chem 276: 8269-8277. Download PDF (1.84MB)

Gelber EI, Kroeze WK, Willins DL, Gray JA, Sinar CA, Hyde EG, Gurevich V, Benovic JL, Roth BL (1999). Structure and function of the third intracellular loop of the 5-hydroxytryptamine2A receptor: the third intracellular loop is alpha-helical and binds purified arrestins. J Neurochem 72:2206-2214. Download PDF (471K)


Book Chapters:

Gray JA and Roth BL (2010). Intraneuronal Signaling. In Sadock BJ, Sadock VA and Ruiz P (Eds.) Kaplan & Sadock’s Comprehensive Textbook of Psychiatry, Lippincott Williams & Wilkins, Philadelphia, PA, in press.

Gray JA and Roth BL (2007). Serotonin Systems. In Sibley D, Hanin I and Kuhar M (Eds.) Handbook of Contemporary Neuropharmacology, John Wiley & Sons, New York, NY, pp 257-298.