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All Clinical Studies

The Clinical Studies Database includes information on major completed and ongoing clinical research supported by the NEI since 1970. This area includes Clinical Trials, Epidemiology and Natural History Studies, and Health Services Research sections of the database.

Table of Contents (alphabetically by study)

Advanced Glaucoma Intervention Study (AGIS)


Age-Related Eye Disease Study (AREDS)


Amblyopia Treatment Study I (ATS I)


Berkeley Orthokeratology Study, The


Branch Vein Occlusion Study


Central Vein Occlusion Study (CVOS)


Clinical Trial of Eye Prophylaxis in the Newborn


Collaborative Corneal Transplantation Studies (CCTS)


Collaborative Initial Glaucoma Treatment Study (CIGTS)


Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study, The


Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study, The


Collaborative Ocular Melanoma Study (COMS)


Complications of Age-Related Macular Degeneration Prevention Trial (CAPT)


Congenital Esotropia Observational Study (CEOS)


Contact Lens and Myopia Progression (CLAMP) Study, The


Cornea Donor Study (CDS)


Correction of Myopia Evaluation Trial (COMET)


Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) - Outcome Study of Cryotherapy for Retinopathy of Prematurity


Diabetic Retinopathy Study (DRS)


Diabetic Retinopathy Vitrectomy Study (DRVS)


Early Manifest Glaucoma Trial (EMGT)


Early Treatment Diabetic Retinopathy Study (ETDRS)


Early Treatment for Retinopathy of Prematurity Study (ETROP)


Effects of Light Reduction on Retinopathy of Prematurity (Light-ROP), The


Endophthalmitis Vitrectomy Study (EVS)


Fluorouracil Filtering Surgery Study (FFSS)


Ganciclovir Implant Study for Cytomegalovirus Retinitis


Glaucoma Laser Trial (GLT)


Glaucoma Laser Trial Followup Study (GLTFS)


Herpetic Eye Disease Study (HEDS) I


Herpetic Eye Disease Study (HEDS) II


Intravenous Immunoglobulin Therapy in Optic Neuritis


Ischemic Optic Neuropathy Decompression Trial (IONDT)


Ischemic Optic Neuropathy Decompression Trial Followup (IONDT Followup)


Krypton-Argon Regression of Neovascularization Study (KARNS)


Longitudinal Optic Neuritis Study (LONS)


Macular Photocoagulation Study (MPS)


Ocular Hypertension Treatment Study (OHTS)


Optic Neuritis Treatment Trial (ONTT)


Prism Adaptation Study (PAS), The


Prospective Evaluation of Radial Keratotomy (PERK) Study


Randomized Trial for Retinitis Pigmentosa


Randomized Trial of Acetazolamide for Uveitis-Associated Cystoid Macular Edema


Randomized Trial of Aspirin and Cataracts in U.S. Physicians


Randomized Trial of Beta-Carotene and Macular Degeneration


Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa


Randomized Trials of Vitamin Supplements and Eye Disease


Safety and Efficacy of a Heparin-Coated Intraocular Lens in Uveitis


The Safety and Efficacy of a Tumor Necrosis Factor Receptor Fusion Protein on Uveitis Associated with Juvenile Rheumatoid Arthritis


Silicone Study, The


Sorbinil Retinopathy Trial (SRT)


Studies of the Ocular Complications of AIDS (SOCA):

Longitudinal Study of Ocular Complications of AIDS (LSOCA)



Ganciclovir-Cidofovir CMV Retinitis Trial (GCCRT)



Cytomegalovirus Retinitis Retreatment Trial (CRRT)



Foscarnet-Ganciclovir CMV Retinitis Trial (FGCRT)



HPMPC Peripheral CMV Retinitis Trial (HPCRT)



Monoclonal Antibody CMV Retinitis Trial (MACRT)


Submacular Surgery Trials (SST)


Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity (the STOP-ROP Multicenter Trial)


Trial of Bifocals in Myopic Children With Esophoria, A





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