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Endocrine Dysfunction:

  1. Endocrine Review
    1. Essentials of Endocrinology


Hypothalamus

Pituitary

 

Thyroid

 

T3/T4


B) Endocrine specificity

    1. Two types of receptors
    1. intracellular receptors
    1. membrane receptors


Endocrine Gland


Hormone

 

 



Kidney Liver Target Tissue Response

 


Excretion Hormone Inactivation


    1. Endocrine Dysfunction

1) Two types of disorders:

a) hyposecretion

b) hypersecretion

2) Two reasons for dysfunction:

    1. Endocrine gland damage
    2. Flaw in the controlling inputs
    1. Endocrine Hypofunction
    1. Hyposecretion
    1. Hormone resistance

Tumor Inadequate Diet Damaged gland Atrophy


 



Agenesis



Genetic Defect HYPOSECRETION

Defective



synthesis

 



Target tissue

receptors



Autoimmune Reduced response to hormone

Damage



Defective target

tissue metabolism


    1. Endocrine Hypersecretion
  1. Thyroid Dysfunction
    1. Background


cold stress



Hypothalamus

TRH



Anterior Pituitary

TSH



Iodine Thyroid

 


T3/T4

Target tissues


    1. Effects
    1. Hypofunction
    1. signs/symptoms
    1. Myxedema
    1. Cretinism
    1. Goiter
    1. Etiology
    1. Therapy
    1. Hyperfunction
    1. signs/symptoms
    1. Graves disease



Hypothalamus


Pituitary

 

TSH


Thyroid Antibodies


T3/T4


    1. Therapy