- Bro. Basilian 
(26th January 1910 to 28th March 1914) 
A French Bro. Director who had improved the academic standards and teaching skills of the teachers. He also extended the old school. He was called to rest in Vietnam on 9th July 1945. 

- Bro. Adrain Edmund 
(29th March 1914 to 27th April 1921) 
He was born in England. Despite the turbulence during World War 1, he kept St. Paul's Institution growing. In 1921, he was transferred to Taiping. He was called to the Lord on the 5th of August 1925 at the age of 54. 

- Bro. Lewis Edward 
(28th April 1921 to January1930) 
An Irish Bro. Director who later founded the St. Paul's Athletic Association which subsequently Became St. Paul's Old Boys Association. Today, it is known as the Old Paulians' Association. He made St. Paul's Institution a force to be reckoned with in the field of soccer and athletics. He also improved the academic results. 

- Bro. Dominic John 
(June 1928 to January 1939) 
An Irish Bro. Director who will always be remembered for establishing the St. Paul's Debating Society. He passed away peacefully on 30th November 1966. 

- Bro. Barnitus Kennedy 
17th January 1930 to 12th August 1931) 
He was born in Ireland. He was a pioneer responsible for the successful implementation of the annual Medical Inspection of the pupils. In 1945, he was appointed as the Bro. Visitor. In 1965, he passed away in Penang and his loss was deeply felt by all Paulians. 

- Bro. John Lynam 
(12th August to 30th June 1933) 
An Irish Bro. Director who faced great hardship during the World Recession. He was transferred to Manila as a Bro. Director and later transferred again to Hong Kong as the Bro. Director of St. Joseph's Hong Kong. He passed away at the ripe age of 78. 

- Bro. Joseph Brophy 
(2nd July 1933 to 4th 1939) 
An Irish Bro. Director who installed the sanitation system of the school. His greatest contributions were the building of the school hall and the upgrading of the school field. Later, he left for Singapore as a Bro. Director. 

- Bro. Anselm Conde 
(4th September 1939 to 11th January 1941) 
He was born in France. A renowned Geography teacher who later became the sub-Director of the school from 1943 to 1965. He was called to rest n Penang on the 5th of May 1969. 
 

- Bro Henry 
(11th January 1941 to December 1946) Born in France in 1886. Bro. Henry devoted 45 years as a member of the La Salle Brothers. He is most well- known for refusing to take down the name "St. Paul's Institution" personally during World War II. He passed away in Pulau Tikus, Penang on the 17th of July 1959 at the age of 75. To fellow Paulians, his death was indeed a sad departure of a beloved comrade. 
 

- Bro. Lawrance Henry 
(3rd February 1947 to 9th 1953) He was the first Malaysian Bro. Director. He helped to rebuild the school after World War II. 21 years later, he breathed his last. 
 

-Bro. Chronan Austin 
(January to October 1953) A Burmese Bro. Director who had served in St. Paul's Institution from January 1939 to January 1940 and from October 1942 to October 1945. 
 

- Bro. Casimir L'Angellier 
(January 1954 to December 1959) Born in Singapore, he became the school's Sub-Director from January 1941 to December 1944. He was the man behind the construction of the new school in Mont La Salle. Under him, the school celebrated her Golden Jubilee and on the same year we celebrated the Golden Jubilee of the arrival of the Brothers to Seremban. He received his PJK in 1957. His death in Hong Kong in the year 1977 was a greatly grieved by all Paulians. 
 

- Bro. Celestine Jennings 
(January 1960 to December 1963) He was born in the land of kangaroos. His efforts to extend the New St.Paul's Institution to the AVA room bore fruit. He died peacefully on August 1st.1991 in Southport, Queensland. 
 

- Bro. Thomas Dunne 
(January 1963 to December 1969) An Irish Bro. Director who was a teacher of the school in 1940. His greatest contributions were renovating the school hall and starting the afternoon session. Under his tenure of office, collections for the poor was healed and our school was the first to have a T.V. set in Negeri Sembilan. He was later transferred to St. Xavier's Institution, Penang. 
 

- Bro. Felix Donahue 
(1st January 1970 to 12th February 1975) He was born in Ireland. For the first time in history, girls were enrolled in Form IV and in Form VI. The renovation of the school office and the school Reference Library was carried out. He was honoured with the PJK award in 1973. In 1975, he was transferred to La Salle P.J. as Bro. Director. 
 

- Bro. James Macken 
(13th February 1975 to 28th February 1991) An Irish Brother who was transferred to St. Paul's Institution from St. Xavier's Institution as The school's Sub-Director. In 1975, he succeeded Bro. Felix Donahue. He is the longest serving Bro. Director.He was a Director of the National College in Kote Kinabalu, Sabah.