| Starship Name | Registry | Class | Description | Episode Or Film | |
| Adelphi, U.S.S. | NCC-26849 | Ambassador | Conducted disastrous first contact with planet Ghorusda. | "Tin Man" (TNG) | |
| Agamemnon, U.S.S. | NCC-11638 | Apollo | Part of the task force for the expected Borg invasion of 2369. | "Descent" (TNG) | |
| Ahwahnee, U.S.S. | NCC-71620 | Cheyenne | Lost in the battle of Wolf 359; named for North American native tribe. | "Best of Both Worlds, Part II" (TNG) | |
| Ajax, U.S.S. | NCC-11574 | Apollo | Corey Zweller's first ship assignment following his graduation; Kosinski tested experimental warp-drive upgrade in 2364. | "Tapestry" (TNG), "Where No One Has Gone Before" (TNG), "Redemption, Part II" (TNG) | |
| Akagi, U.S.S. | NCC-62158 | Rigel | Part of Picard's blockade armada in 2368. | "Redemption, Part II" (TNG) | |
| Al-Batani, U.S.S. | NCC-42995 | Excelsior | Janeway served as science officer under Captain Paris | "Caretaker" (VGR) | |
| Antares, U.S.S. | NCC-501 | Antares | Science vessel; destroyed by Charles Evans. | "Charlie X" (TOS) | |
| Appalacia, U.S.S. | NCC-52136 | Steamrunner | Defended Earth against Borg incursion of 2373. | Star Trek: First Contact | |
| Archon, U.S.S. | NCC-189 | Daedalus | Early starship; lost at planet Beta III in 2167. | "Return of the Archons" (TOS) | |
| Arcos, U.S.S. | NCC-6237 | Deneva | Freighter ship; lost near planet Turkana IV. | "Legacy" (TNG) | |
| Aries, U.S.S. | NCC-45167 | Renaissance | Riker was offered command in 2365. | "The Icarus Factor" (TNG), "Identify Crisis" (TNG) | |
| Armstrong, U.S.S. | NCC-57537 | Challenger | Ambushed by Klingon battle group in 2373; named for Apollo 11 astronaut Neil Armstrong. | "Apocalypse Rising" (DS9) | |
| Bellerephon, U.S.S. | NCC-62048 | Nebula | Lost in the battle of Wolf 359; named for the ship from Forbidden Planet. | "Emissary" (DS9) | |
| Berlin, U.S.S. | NCC-14232 | Excelsior | Stationed near Romulan Neutral Zone in 2364. | "Angel One" (TNG) | |
| Biko, U.S.S. | NCC-50331 | Olympic | Scheduled to rendezvous with Enterprise-D on stardate 46271. | "A Fistful of Datas" (TNG) | |
| Bonestell, U.S.S. | NCC-31600 | Oberth | Lost in the battle of Wolf 359; named for astronomical artist Chesley Bonestell. | "The Best of Both Worlds, Part II (TNG) | |
| Bozeman, U.S.S. | NCC-1941 | Soyuz | Caught in a temporal causality loop in 2278; escaped in 2368; named for the city of Bozeman, Montana. | "Cause and Effect" (TNG), "All Good Things..." (TNG), Star Trek: First Contact | |
| Bradbury, U.S.S. | NX-72307 | Bradbury | Transported Wesley Crusher to Starfleet Academy in 2366. | "Menage a Troi" (TNG) | |
| Brattain, U.S.S. | NCC-21166 | Miranda | Trapped in a Tyken's Rift in 2367. | "Night Terrors" (TNG) | |
| Budapest, U.S.S. | NCC-64923 | Norway | Defended Earth against Borg incursion of 2373. | Star Trek: First Contact | |
| Buran, U.S.S. | NCC-57580 | Challenger | Lost in the battle of Wolf 359. | "The Best of Both Worlds, Part II (TNG) | |
| Cairo, U.S.S. | NCC-42136 | Excelsior | Commanded by Captain Edward Jellico | "Chain of Command, Part I" (TNG), "Preemptive Strike" (TNG) | |
| Carolina, U.S.S. | NCC-160 | Daedalus | Apparently sent emergency signal. | "Friday's Child" (TOS) | |
| Charleston, U.S.S. | NCC-42285 | Excelsior | Transported 20th-Century survivors back to Earth | "The Neutral Zone" (TNG) | |
| Chekov, U.S.S. | NCC-53702 | Springfield | Lost in the battle of Wolf 359; named for the noted Russian space explorer. | "The Best of Both Worlds, Part II" (TNG) | |
| Clement, U.S.S. | NCC-12537 | Apollo | Scheduled To rendezvous with the Enterprise-D | "Lower Decks" (TNG) | |
| Cochrane, U.S.S. | NCC-59318 | Oberth | Transported Bashir to Deep Space 9; named for the inventor of warp drive. | "Emissary" (DS9) | |
| Columbia, U.S.S. | NCC-621 | Unknown | Ordered To rendezvous with the Revere. | Star Trek: The Motion Picture | |
| Concord, U.S.S. | NCC-68711 | Freedom | (In anti-time, deployed to Romulan Neutral Zone) | "All Good Things..." (TNG) | |
| Constantinople, U.S.S. | NCC-34852 | Istanbul | Suffered hull breach near Gravesworld in 2365. | "The Schizoid Man" (TNG) | |
| Constellation U.S.S. | NCC-1974 | Constellation | Transported Jem'Hadar To Starbase 201 | "The Abandoned (DS9) | |
| Constellation U.S.S. | NCC-1017 | Constitution | Commanded by Matt Decker; destroyed in encounter with planet killer. | "The Doomsday Machine" (TOS) | |
| Constitution U.S.S. | NCC-1700 | Constitution | Class prototype ship for original starship Enterprise; named for "Old Ironsides" | "Space Seed" (TOS) | |
| Copernicus, U.S.S. | NCC-623 | Oberth | In space dock at the time the second Enterprise was launched | Star Trek IV: The Voyage Home | |
| Crazy Horse, U.S.S. | NCC-50446 | Excelsior | Part of task force 3 during expected Borg invasion of 2369. | "The Pegasus" (TNG) | |
| Crockett, U.S.S. | NCC-38955 | Excelsior | Transported Admiral Mitsuya to Deep Space 9. | "Paradise" (DS9) | |
| Defiant, U.S.S. | NCC-1764 | Constitution | Lost in spatial interphase. | "The Tholian Web" (TOS) | |
| Defiant, U.S.S. | NX-74205 | Defiant | Small, heavily armed prototype intended to defend against the borg; assigned to station Deep Space 9. | "The Search, Parts I & II" DS9), Star Trek: Deep Space Nine, Star Trek: First Contact | |
| Denver, U.S.S. | NCC-54927 | Yorkshire | Struck gravitic mine in 2368 | "Ethics" (TNG) | |
| Drake, U.S.S. | NCC-20381 | AWambundu | Destroyed by ancient weapons system at Minos. | "The Arsenal of Freedom" (TNG) | |
| Drake, U.S.S. | NCC-70956 | Andromeda | Ambushed by Klingon battle group in 2373. | "Apocalypse Rising (DS9) | |
| Eagle, U.S.S. | NCC-956 | Constitution | Potential participant in Operation Retrieve. | Star Trek VI: The Undiscovered Country | |
| Endeavor, U.S.S. | NCC-71805 | Nebula | Served in Romulan blockade during Klingon civil war; part of armada that intercepted Borg ship. | "Redemption, Part II" (TNG), "The Game" (DS9) | |
| Enterprise, U.S.S. | NCC-1701 | Constitution | First starship to bear the name; commanded by Captain James T. Kirk. | Star Trek: The Original series, Star Trek: The Motion Picture, Star Trek II: The Wrath of Khan, Star Trek III: The Search for Spock | |
| Enterprise-A, U.S.S. | NCC-1701-A | Constitution | Second starship to bear the name; refit constitution-class design. | Star Trek IV: The Voyage Home | |
| Enterprise-B, U.S.S. | NCC-1701-B | Excelsior | Launched in 2293 under the command of Captain John Harriman. | Star Trek Generations | |
| Enterprise-C, U.S.S. | NCC-1701-C | Ambassador | Lost and presumed destroyed near Narendra III in 2344 under command of Rachel Garrett | "Yesterday's Enterprise" (TNG) | |
| Enterprise-D, U.S.S. | NCC-1701-D | Galaxy | Fifth starship to bear the name; commanded by Captain Jean-Luc Picard | Star Trek: The Next Generation, Star Trek Generations | |
| Enterprise-E, U.S.S. | NCC-1701-E | Sovereign | Sixth starship to bear the name; launched in 2373 under command of Jean-Luc Picard. | Star Trek: First Contact, Star Trek: Insurrection | |
| Essex, U.S.S. | NCC-173 | Daedalus | Lost in 2167 at planet Mab-bu VI. | "Power Play" (TNG) | |
| Excalibur, U.S.S. | NCC-1664 | Constitution | Seriously damaged in M-5 test in 2268. | "The Ultimate Computer" (TOS) | |
| Excalibur, U.S.S. | NCC-26517 | Ambassador | Part of Romulan blockade in 2368. | Redemption, Part II" (TNG) | |
| Excelsior, U.S.S. | NX-2000; (later NCC-2000) | Excelsior | Testbed for transwarp development project; later commanded by Captain Hikaru Sulu; prototype for Excelsior-class starships. | Star Trek III: The Search For Spock, Star Trek VI: The Undiscovered Country, "Flashback" (VGR) | |
| Exeter, U.S.S. | NCC-1672 | Constitution | Crew killed by bacteriological warfare agent at Omega IV in 2268. | "The Omega Glory" (TOS) | |
| Exeter, U.S.S. | NCC-26531 | Ambassador | Former posting of Tom Paris. | "Non sequitur" (VGR) | |
| Farragut, U.S.S. | NCC-1647 | Constitution | Kirks's first assignment after the academy. | "Obsession" (TOS) | |
| Farragut, U.S.S. | NCC-60591 | Nebula | Rescued crew of Enterprise-D at Veridian III in 2371; later destroyed near Ajilon Prime. | Star Trek Generations, "Nor the Battle to the Strong" (DS9) | |
| Fearless, U.S.S. | NCC-4598 | Excelsior | Testbed for Kosinski's experimental warp engine upgrades. | "Where No One Has Gone Before" (TNG) | |
| Firebrand, U.S.S. | NCC-68723 | Freedom | Lost in the battle of Wolf 359 | "The Best of Both Worlds, Part II" (TNG) | |
| Fleming, U.S.S. | NCC-20316 | Wambundu | Destroyed in Hekaras Corridor in 2370. | "Force of Nature" (TNG) | |
| Gage, U.S.S. | NCC-11672 | Apollo | Lost in the battle of Wolf 359. | "Emissary" (DS9) | |
| Galaxy, U.S.S. | NCC-70637 | Galaxy | Class prototype for fifth Starship Enterprise. | Star Trek: The Next Generation | |
| Gandhi, U.S.S. | NCC-26632 | Ambassador | Thomas Riker assigned to Gandhi in 2369. | "Second Chances" (TNG) | |
| Ganges, U.S.S. | NCC-72454 | Danube | Runabout assigned to Deep Space 9. | "Past Prologue" (DS9), "Q-Less" (DS9), et al | |
| Gettysburg, U.S.S. | NCC-3890 | Constellation | Last ship commanded by Mark Jameson before his promotion to admiral. | "Too Short A Season" (TNG) | |
| Goddard, U.S.S. | NCC-59621 | Korolev | Part of tachyon detection grid during Klingon civil war. | "The Vengeance Factor" (TNG), "Redemption, Part II" (TNG) | |
| Gorkon, U.S.S. | NCC-40512 | Excelsior | Admiral Nechayev's flagship in 2369. | "Descent, Part I" (TNG) | |
| Grissom, U.S.S. | NCC-638 | Oberth | Science vessel; destroyed at Genesis Planet. | Star Trek III: The Search for Spock | |
| Grissom, U.S.S. | NCC-42857 | Excelsior | Second Federation ship to bear the name. | "The Most Toys" (TNG) | |
| Hathaway, U.S.S. | NCC-2593 | Constellation | Participated in Starfleet battle simulation. | "peak Performance" (TNG) | |
| Havana, U.S.S. | NCC-34043 | Istanbul | Scheduled to rendezvous with Enterprise-D in 2369. | "Lessons" (TNG) | |
| Hera, U.S.S. | NCC-62006 | Nebula | Commanded by Silva La Forge. | "Interface" (TNG) | |
| Hermes, U.S.S. | NCC-10376 | Antares | Served in armada during Klingon civil war. | "Redemption, Part II" (TNG) | |
| Hood, U.S.S. | NCC-42296 | Excelsior | Commanded by Robert DeSoto; Riker's posting prior to Enterprise-D. | "Encounter at Farpoint" (TNG), "Tin Man" (TNG), et al | |
| Hood, U.S.S. | NCC-1703 | Constitution | Participated in M-5 multitronic computer test. | "The Ultimate Computer" (TOS) | |
| Horatio, U.S.S. | NCC-10532 | Ambassador | Destroyed at Dytallix B in 2364. | "Conspiracy" (TNG) | |
| Horizon, U.S.S. | NCC-176 | Daedalus | Lost in 2168 after visiting Sigma lotia II. | "A Piece of the Action" (TOS) | |
| Hornet, U.S.S. | NCC-45231 | Renaissance | Served in armada during Klingon civil war. | "Redemption, Part II" (TNG) | |
| Intrepid, U.S.S. | NCC-1631 | Constitution | Destroyed by spaceborne amoeba in 2268. | "Court Martial" (TOS), "The Immunity Syndrome" (TOS) | |
| Intrepid, U.S.S. | NCC-38907 | Excelsior | First ship to respond to distress calls after Khitomer massacre. | "Sins of the Father" (TNG), "Family" (TNG) | |
| Jenolen, U.S.S. | NCC-2010 | Sydney | Transport ship lost in 2294 carrying Montgomery Scott. | "Relics" (TNG) | |
| Kearsarge, U.S.S. | NCC-57566 | Challenger | Scheduled to rendezvous with Enterprise-D in 2370. | "Firstborn" (TNG) | |
| Kyushu, U.S.S. | NCC-65491 | New Orleans | Lost in the battle of Wolf 359. | "The Best of Both Worlds, Part II" (TNG) | |
| LaSalle, U.S.S. | NCC-6203 | Deneva | Reported radiation anomalies in 2367. | "Reunion" (TNG) | |
| Lakota, U.S.S. | NCC-42768 | Excelsior | Tried to stop Defiant during Leyton's attempted coup in 2372. | "Homefront" (DS9), "Paradise Lost" (DS9) | |
| Lalo, U.S.S. | NCC-43837 | Mediterranean | Detected Manheim's time/gravity experiments; believed lost in Borg attack. | "We'll Always Have Paris" (TNG), "The Best of Both Worlds, Part I" (TNG) | |
| Lantree, U.S.S. | NCC-1837 | Miranda | Crew killed by genetically-engineered children. | "Unnatural Selection" (TNG) | |
| Lexington, U.S.S. | NCC-1709 | Constitution | Commanded by Commodore Robert Wesley; participated in M-5 tests. | "The Ultimate Computer" (TOS) | |
| Lexington, U.S.S. | NCC-14427 | Excelsior | Transported medical supplies for Taranko colony. | "Thine Own Self" (TNG) | |
| Lexington, U.S.S. | NCC-61832 | Nebula | Visited Deep Space 9 in 2371. | "Explorers" (DS9) | |
| Livingston, U.S.S. | NCC-34099 | Excelsior | Benjamin Sisko and Curzon Dax once served aboard the Livingston. | "Invasive Procedures" (DS9) | |
| Magellan, U.S.S. | NCC-3069 | Constellation | Commanded by Captain Conklin. | "Starship Mine" (TNG) | |
| Malinche, U.S.S. | NCC-38997 | Excelsior | Attacked by Maquis forces. | "For the Uniform" (DS9) | |
| Maryland, U.S.S. | NCC-45109 | Renaissance | Lost in the Gamma Quadrant. | "In Purgatory's Shadow" (DS9) | |
| Mekong, U.S.S. | NCC-72917 | Danube | Runabout assigned to Deep Space 9. | "The Maquis, Part II" (DS9), "Whisper's" (DS9) | |
| Melbourne, U.S.S. | NCC-62043 | Excelsior | Lost in the battle of Wolf 359. | "11001001" (TNG), "The Best of Both Worlds" (TNG), "Emissary" (DS9) | |
| Merrimack, U.S.S. | NCC-61827 | Nebula | Transported Ambassador Sarek back to Vulcan in 2366. | "Sarek" TNG), "The Game" (TNG) | |
| Monitor, U.S.S. | NCC-61826 | Nebula | Assigned to Romulan Neutral Zone in 2366. | "The Defector" (TNG) | |
| Nobel, U.S.S. | NCC-55012 | Olympic | Searched for U.S.S. Hera in 2370. | "Interface" (TNG) | |
| Odyssey, U.S.S. | NCC-71832 | Galaxy | Destoyed by Jem'Hadar in 2370. | "The Jem'Hadar" (DS9) | |
| Okinawa, U.S.S. | NCC-13958 | Excelsior | Sisko's posting prior to Saratoga. | "Homefront" (DS9), "Paradise Lost" (DS9) | |
| Orinoco, U.S.S. | NCC-72905 | Danube | Runabout assigned to Deep Space 9; destoyed be Cardassian radicals. | "The Siege" (DS9), "The Maquis, Part II" (DS9), "Whispers" (DS9) | |
| Pasteur, U.S.S. | NCC-58928 | Olympic | (In anti-time future, a medical ship commanded by Beverly Crusher.) | "All Good Things..." (TNG) | |
| Pegasus, U.S.S. | NCC-53847 | Oberth | Destroyed during illegal test of Federation cloaking device; Riker's first posting. | "The Pegasus" (TNG) | |
| Phoenix, U.S.S. | NCC-65420 | Nebula | Commanded by Benjaman Maxwell; launched illegal offensive against Cardassians. | "The Wounded" (TNG) | |
| Portland, U.S.S. | NCC-57418 | Chimera | Searched for Odo and Garak in Algira sector. | "The Die is Cast" (DS9) | |
| Potemkin, U.S.S. | NCC-1657 | Constitution | Participated in M-5 tests in 2268. | "The Ultimate Computer" (TOS), "Turnabout Intruder" (TOS) | |
| Potemkin, U.S.S. | NCC-18253 | Excelsior | Riker's early posting, prior to Hood and Enterprise-D. | "Peak Performance" (TNG), "Second Chances" (TNG) | |
| Princeton, U.S.S. | NCC-59804 | Niagara | Lost in the battle of Wolf 359. | "The Best of Both Worlds, Part II" (TNG) | |
| Prokofiev, U.S.S. | NCC-68814 | Andromeda | Dispatched to the Demilitarized Zone in 2370. | "Tribunal" (DS9) | |
| Prometheus, U.S.S. | NCC-71201 | Nebula | Participated in re-ignition of star Epsilon 119. | "Second Sight" (DS9) | |
| Prometheus, U.S.S. | NX-59650 | Prometheus | This is an experimental prototype starship designed for deep space tactical assignments, and fitted with a whole range of new and secret technology. | Info Unavailable | |
| Proxima, U.S.S. | NCC-61952 | Nebula | Believed lost to Dominion forces. | "In Purgatory's Shadow" (DS9) | |
| Raman, U.S.S. | NCC-59983 | Oberth | Science vessel lost at Marijne VII. | "Interface" (TNG) | |
| Raven, U.S.S. | NAR-32450 | Unknown | A research vessel that was assimilated by the Borg and destroyed. | Info Unavailable | |
| Reliant, U.S.S. | NCC-1864 | Miranda | Participated in Project Genesis. | Star Trek II: The Wrath of Khan | |
| Renegade, U.S.S. | NCC-63102 | New Orleans | Met Enterprise-D at Dutallix B. | "Conspiracy" (TNG) | |
| Republic, U.S.S. | NCC-1371 | Constitution | Ensign Kirk's posting , along with Ben Finney. | "Court Martial" (TOS) | |
| Repulse, U.S.S. | NCC-2544 | Excelsior | Katherine Pulaski's posting prior to Enterprise-D. | "The Child" (TNG), "Unatural Selection" (TNG) | |
| Revere, U.S.S. | NCC-595 | Unknown | Ordered to rendezvous with U.S.S. Columbia. | Star trek: The Motion Picture | |
| Rio Grande, U.S.S. | NCC-72452 | Danube | Runabout assigned to Deep Space 9. | "Emissary" (DS9), et al | |
| Roosevelt, U.S.S. | NCC-2573 | Excelsior | Lost in the battle of Wolf 359; named for American president Theodore Roosevelt. | "Unity" (VGR) | |
| Rubicon, U.S.S. | NCC-72936 | Danube | Runabout assigned to Deep Space 9. | "Family Business" (DS9), "Hippocratic Oath" (DS9) | |
| Rutledge, U.S.S. | NCC-57295 | New Orleans | Miles O'Brian's posting during the Cardassian war. | "The Wounded" (TNG), "Paradise" (DS9) | |
| Sarajevo, U.S.S. | NCC-38529 | Istanbul | Believed lost to Dominion forces. | "In Purgatory's Shadow" (DS9) | |
| Saratoga, U.S.S. | NCC-1937 | Miranda | Disabled by alien space probe in 2286. | Star Trek IV: The Voyage Home | |
| Stargazer, U.S.S. | NCC-2893 | Constellation | Picard's former command: lost in the Battle of Maxia. | "The Battle" (TNG), "Measure of a Man" (TNG), "Tapestry" (TNG) | |
| Sutherland, U.S.S. | NCC-72015 | Nebula | Commanded by Data during Picards's blockade of Romulan ships in 2368. | "Redemption, Part II" (TNG) | |
| T'pau | NSP-17938 | Apollo | Ship of Vulcan registry; decommissioned in 2364. | "Unification, Part I" (TNG) | |
| Tecumseh, U.S.S. | NCC-14934 | Excelsior | Participated in counterattack against Klingon forces in 2373. | "Nor the Battle to the Strong" (DS9) | |
| Thomas Paine, U.S.S. | NCC-65530 | New Orleans | Met Enterprise-D at Dytallix B in 2364. | "Conspiracy" (TNG) | |
| Thunderchild, U.S.S. | NCC-63549 | Akira | Defended sector 001 against Borg incursion of 2373. | Star Trek: First Contact | |
| Tian An Men, U.S.S. | NCC-21382 | Miranda | Participated in Picard's blockade of Romulan ships in 2368. | "Redemption, Part II" (TNG) | |
| Tolstoy, U.S.S. | NCC-62095 | Rigel | Lost in the battle of Wolf 359; named for Russian author Leo Tolstoy. | "The Best of Both Worlds, Part II" (TNG) | |
| Trieste, U.S.S. | NCC-37124 | Merced | Data's posting prior to Enterprise-D. | "Clues" (TNG), "11001001" (TNG) | |
| Tripoli, U.S.S. | NCC-19386 | Hokule'a | Discovered Data at Omicron Theta colony in 2338. | "Datalore" (TNG), "Unification, Part I" (TNG) | |
| Tsiolkovsky, U.S.S. | NCC-53911 | Oberth | Crew killed by Psi 2000 virus in 2364; named for Russian space pioneer Konstantin Tsiolkovsky. | "The Naked Now" (TNG) | |
| Ulysses, U.S.S. | NCC-66808 | Nebula | Did scientific study in the Helsaport Nebula. | "The Adversary" (DS9) | |
| Valdemar, U.S.S. | NCC-26198 | Ambassador | Dispatched to Demilitarized Zone in 2370. | "Tribunal" (DS9) | |
| Valiant, U.S.S. | NCC-1223 | Unknown | Destroyed at Eminiar VII in 2217. | "A Taste of Armageddon" (TOS) | |
| Venture, U.S.S. | NCC-71854 | Galaxy | Led relief force to Deep Space 9 in 2372. | "The Way of the Warrior" (DS9) | |
| Vico, U.S.S. | NAR-18834 | Oberth | Research vessel, lost in Black Cluster. | "Hero Worship" (TNG) | |
| Victory, U.S.S. | NCC-9754 | Constellation | Geordi La Forge's posting prior to Enterprise-D. | "Elementary, Dear Data" (TNG), "Identity Crisis" (TNG) | |
| Volga, U.S.S. | NCC-73196 | Danube | Runabout assigned to Deep Space 9. | "Body Parts" (DS9) | |
| Voyager, U.S.S. | NCC-74656 | Intrepid | Lost in Delta Quadrant. | Star Trek: Voyager | |
| Wellington, U.S.S. | NCC-28473 | Niagara | Serviced at Starbase 74 on 2364; Ro's former posting. | "11001001" (TNG), "Remember Me" (TNG), "Ensign Ro" (TNG) | |
| Wyoming, U.S.S. | NCC-43730 | Mediterranean | Tuvok served aboard Wyoming in 2349. | "Flashback" (VGR) | |
| Yamato, U.S.S. | NCC-71807 | Galaxy | Destroyed by Iconian software weapon in 2365. | "Where Silence Has Lease" (TNG), "Contagion" (TNG) | |
| Yangtzee Kiang, U.S.S. | NCC-72453 | Danube | Runabout assigned to Deep Space 9. | "Emissary" (DS9), "Battle Lines" (DS9) | |
| Yeager, U.S.S. | NCC-61947 | Saber | Defended Sector 001 against Borg incursion. | Star Trek: First Contact | |
| Yellowstone, U.S.S. | NCC-70073 | Sequoia | Transported Melora Pazlar to Deep Space 9. | "Melora" (DS9) | |
| Yellowstone, U.S.S. | NX-74751 | Yellowstone | Prototype for advanced runabout. | "Non Sequitur" (VGR) | |
| Yorktown, U.S.S. | NCC-1717 | Constitution | Scheduled to rendezvous with Enterprise in 2268. | "Obession" (TOS), Star Trek IV: The Voyage Home | |
| Yorktown, U.S.S. | NCC-61137 | Zodiac | (In anti-time future, ordered to make long-range sensor scans of Devron system) | "All Good Things" (TNG) | |
| Yosemite, U.S.S. | NCC-19002 | Oberth | Science vessel; damaged while investigating plasma streamers. | "Realm of Fear" (TNG) | |
| Yukon, U.S.S. | NCC-74602 | Danube | Runabout assigned to Deep Space 9. | "Sons of Mogh" (DS9) | |
| Zapata, U.S.S. | NCC-33184 | Surak | Scheduled to rendezvous with Enterprise-D. | "Menage a Troi" (TNG) | |
| Zhukov, U.S.S. | NCC-26136 | Ambassador | Reginald Barclay was assigned to Zhukov prior to Enterprise-D. | "Hollow Pursuits" (TNG), "Data's Day" (TNG), "The GAme" (TNG) |
| Known Federation Starfleet Prefixes | Known Federation Non-Starfleet prefixes |
| NCC: Starfleet, active service | BDR: non-Starfleet |
| NX: Starfleet, experimental | NAR: non-Starfleet, research |
| NCV: Starfleet timeship, 29th century | NDT: non-Starfleet, transport |
| NFT: non-Starfleet, transport | |
| NGL: non-Starfleet, freighter | |
| NSP: Vulcan, science |
