General view: Glucose(6-carbon sugar) being break down into:
==> 2 incomplete pyruvates (3-carbon pyruvates)
==> 2 NADH + H+
==> 2 ATPs
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::: Glycolysis begins :::
::::::::::::::::::::::::::::::::::::::::::::::::Energy investing reactions (1 - 5):::::::::::::::::::::::::::::::::::::::::::::::::
Reaction 1:
ATP transfer a phosphate to C6H12O6 ==> glucose 6 phosphate (G6P)
Enzyme used: Hexokinase
Reaction 2:
G6P ==> fructose 6 phosphate (F6P)
Enzyme: Phosphohexose isomerase
Reaction 3:
A 2nd ATP transfer a phosphate (ATP ==> ADP) ==> fructose 1, 6-biphosphate (FBP)
Enzyme: Phosphofructokinase
Reaction 4:
FBP ==> DAP + G3P (these 2 are isomers of each other)
Enzyme: Aldolase
Reaction 5:
DAP ==> G3P (by rearrangement) / Now we have 2 G3Ps
Enzyme: Iomerase
++++++++ At this point : 2 ATP is invested
++++++++++++++++++ C6H12O6 ==> 2 G3Ps
++++++++++++++++++ No ATP is gained
++++++++++++++++++ Nothing is oxidized
::::::::::::::::::::::::::::::::::::::::::::::::Energy harvesting reactions (6-10):::::::::::::::::::::::::::::::::::::::::::::::::
Reaction 6:
2 G3Ps gain phosphate group and oxidized (very exergonic) ==> 2 NADH + H+
==> 2 BPGs
Enzyme: Triose phosphate dehydrogenase
Reaction 7:
2 BPGs transfer phosphate group to ADP ==> ATP
==> 2 3PGs
Enzyme: Phosphoglycerate kinase
Reaction 8:
3PGs ==> 2PGs
Reaction 9:
2PGs lose H2O(water) ==> PEP (high energy phosphoenolpyruvates)
Enzyme: Enolase
Reaction 10:
2 PEPs transfer phosphate to ADP ==> 2 ATPs and 2 pyruvate!