Rosacea

[1] http://www.drnase.com - Microvascular Physiologist and rosacea sufferer writes his long-awaited book.

http://rosacea.ii.net/gnase/index.html - Can see some before/after pictures of Dr. Nase here.

[2] http://groups.yahoo.com/group/rosacea-support - Excellent Searchable Rosacea Support Group Of Over 2000 Members.

http://www.escribe.com/health/rosacea-support - A complementary daily threaded format archive.

[3] http://www.dreamwater.com/hyperhid/weblist2.html - Other great links already here.

[4] http://www.acne-rosacea.co.uk - Interesting Website on Rosacea & Acne, emotional aspects & Aloe Vera Products. 

[5] Rosacea from emedicine.com - For papular/pustular rosacea & redness/flushing, I'd recommend considering more caution than mentioned at that link with isotretinoin/Accutane dosing if considering it as suggested here Efficacy of Low-Dose Isotretinoin in Patients With Treatment-Resistant Rosacea & by the experience of Yahoo rosacea group members & thoroughly discussed in Dr. Nase's book.

* NEW *  - LATEST NEWS -

Notice: * I made the mistaken assumption that everyone who would visit this page by now has a copy of Dr. Nase's book so they would recognize the news listed here is largely follow-ups on subjects presented in his wonderful book. I encourage people to buy a copy of his groundbreaking book as this page does not intend substitute or compete with his book & website efforts. I merely wish to coalesce group endeavors & give people hope that progress continues while Dr. Nase recovers from his unfortunate accident he mentioned at the rosacea group in his recent update on future plans here. I have already apologized to him & hope to establish a productive relationship where his catalytic work can continue to work all its magic. Bring in or buy an extra copy for your doctors (a real bargain compared to the doctor visit)! Get the richly detailed, full scoop from his book available at his website http://www.drnase.com . I simply can not support this unaffiliated researcher's efforts enough. *

New: Lessons from chronic pain & neurovascularplasticity here

New : Candela Q & A Email Interview on Pulse Dye Lasers & their new Vbeam here

New :  http://www.aad.org/DermSearch - Find a dermatologist by State, City, Area Code, Zip Code, Country

- Great site on established treatments for dry eye including videos on proper cleaning & punctum plug treatment here.

- Ocular Rosacea/ Dry Eye News - Topical cyclosporine seems safe & effective

http://www.pslgroup.com/dg/dermanews.htm - News Dermatological Disorders (regularly updated site) - Including 60th (AAD) Annual meeting of the American Academy of Dermatology News

Immunomodulators theme at 59th AAD? - Tacrolimus Ointment (Protopic)/ Oral/Ascomycin Cream, nonablative lasers, stress effects, etc... - I'm Curious about the potential of Topical Ocular Ascomycins for dry eye considering its preliminary superior systemic safety profile

1) Post on Cause? here

2) Moxonidine Vs. Clonidine , New: Tizanidine/Zanaflex - Alternative?

3) The Response of Erythematous Rosacea & Ocular Rosacea to ondansetron / Zofran Article & New Neurotransmitters & Flushing article

4) Erythromelalgia (EM), Raynauds, CRPS-RSD/Causalgia, Cluster Headaches, Facial Neuralgias - Lessons to be learned for rosacea? here * New

5) My recent posts on NO modulation here & here

Subject:  Formulating Topical NOS inhibitors now - Shall we?   Topical NO trials (Full Topic thread) - Oral NO inhibitors one day? - NOSI Antidepressants ?

http://www.tocris.com/  

& specifically: http://www.tocris.com/cat/nonselect.html 

NO may be the final mediator in vasodilation (redness, flushing) as Dr. Nase discusses in his book. He did a successful experiment with 1% L-NAME (from Sigma Chemicals in a water-based cream that he developed in his lab but a compounding pharmacy may be able to formulate a comparable effective non-irritating delivery system).  L-NAME is listed above as well as other potentially more potent ones.

There have been concerns about possible problematic preservatives that are worth asking about so I also include the company info on the source mentioned in Dr. Nase's book:

Sigma Chemical Company

6050 Spruce St.
St. Louis, MO 63103
________________________

Company Phone: (314) 771-5750
US Toll Free: (800) 325-3010
FAX Number: (800) 325-5052
________________________

E-mail: sigma@sial.com
Company URL:www.sigma.sial.com

Also:

P.O. Box 14508, St. Louis, MO 63178-9916
USA
Tel: 1-800-325-8070
Web: www.sigma-aldrich.com

Your Company search for: L-NAME
Was found in 2 out of 215381 documents searched. 
Page: 1 
72760 Nw-Nitro-L-arginine methyl ester hydrochloride 
puriss., ³ 99.0 % (AT) , L-NAME , 51298-62-5 

N5751 Nomega-Nitro-L-Arginine Methyl Ester Hydrochloride 
Minimum 98% (TLC) , L-NAME , 51298-62-5 
White to off-white powder 

PDF Product Info document on N5751

- Oral NO inhibitors one day? , NOSI Antidepressants ?

6) Topical Strontium Nitrate Moisturizer & Strontium Nitrate Spray - from http://www.rosaceacare.com reportedly should become available in October & November/December respectively to be formulated for rosacea skin.   Not very enthusiastic review so far here

* Topical Strontium Products available now here at http://www.cosmederm.com?  I should have some products to review this week & have emailed the creator on the suitability of current products for rosacea. * Quick Review- Wait & see since I don't think the current batch are ideal for vasoactive rosacea skin.*

Dermatol Surg 1999 Sep;25(9):689-94

Strontium is a potent and selective inhibitor of sensory irritation.

Hahn GS.

Immunology and Allergy Division, Department of Pediatrics, University of California, San Diego, USA.

BACKGROUND: Irritant contact dermatitis occurs following topical exposure to many chemicals found in cosmetics, personal care products, drugs, and during occupational exposure. Signs and symptoms may include sensory irritation (sting, burn, and/or itch), erythema, edema, and vesiculation. OBJECTIVE: In an attempt to discover new classes of anti-irritant compounds without anesthetic properties, I observed that topical application of strontium salts to intact skin produced potent suppression of sting, burn, and itch caused by many irritant chemicals. METHODS: Chemically and biologically unrelated irritants were applied with or without strontium salts to the skin of healthy women with self-reported sensitive skin in double-blind, vehicle-controlled, random-treatment assignment trials and sensory irritation was assessed. RESULTS: Strontium application as a pretreatment or mixed with the irritant substantially suppressed sensory irritation without local anesthetic side-effects. CONCLUSION: Strontium salts represent a new class of selective inhibitors of sensory irritation and irritant dermatitis.

 

Contact Dermatitis 2000 Feb;42(2):98-100

Strontium nitrate suppresses chemically-induced sensory irritation in humans.

Zhai H, Hannon W, Hahn GS, Pelosi A, Harper RA, Maibach HI.

Department of Dermatology, University of California, School of Medicine, San Francisco 94143-0989, USA.

Skin care products are complex formulations that may cause sensory irritation symptoms, characterized by stinging, burning, and itching. Substances capable of counteracting sensory irritation are of great practical interest. Strontium salts have been demonstrated to inhibit sensory irritation and inflammation when applied topically. In this double-blind study, we evaluated the efficacy of strontium nitrate in reducing chemically-induced skin sensory irritation in 8 subjects. In a random order, 20% strontium nitrate in 70% glycolic acid (pH=0.6) (mixture) was applied to the volar aspect of the forearm and a positive control (70% glycolic acid, pH=0.6) to the contralateral forearm. The irritation sensation was evaluated each min for the first 20 min after topical application using a scale from 0-4. The duration of the irritation sensation in min was also recorded. Strontium nitrate mixed with glycolic acid, in comparison with glycolic acid alone, markedly (p<0.01) shortened the duration of the irritation sensation from 24.4+/-4.1 (mean+/-SEM) min to 8.9+/-3.7 (mean+/-SEM) min, and significantly (p<0.05) reduced the mean magnitude of the irritation sensation at all time points (overall). The study demonstrated that strontium nitrate potently suppresses the sensation of chemically-induced irritation.

 

7) Immunomodulators theme at 59th Annual Meeting of the American Academy of Dermatology? - Tacrolimus Ointment (Protopic)/ Oral/Ascomycin Cream, nonablative lasers, stress effects, etc...

Protopic - alternative to steroids?

http://www.protopic.com

J Am Acad Dermatol 2001 Jun;44(6):995-8

Tacrolimus ointment for the treatment of steroid-induced rosacea: a preliminary report.

Goldman D.

Department of Dermatology, NorthBay Healthcare Medical Group, Fairfield, CA 94533, USA. drdavidgoldman@msn.com

BACKGROUND: Excessive topical corticosteroid application to facial areas commonly leads to steroid-induced rosacea. This may be a recalcitrant problem that requires months of antibiotic and anti-inflammatory therapy before it resolves. OBJECTIVE: The purpose of this article is to review the use of tacrolimus ointment, a macrolide anti-inflammatory ointment for the treatment of 3 patients with steroid-induced rosacea. METHODS: Three patients with steroid-induced rosacea applied tacrolimus ointment, 0.075% twice daily for 7 to 10 days. Patients were also instructed to avoid topical corticosteroid use and other rosacea-aggravating substances including caffeine, spicy foods, alcohol, hot fluids, and fluoride. Patients were observed for tenderness, erythema, and relief of pruritus. RESULTS: Pruritus, tenderness, and erythema were resolved in all 3 patients after 7 to 10 consecutive days' use of tacrolimus 0.075% ointment in conjunction with avoidance of topical steroids, caffeine, spicy food, alcohol, hot fluids, and fluoride. CONCLUSION: This preliminary study demonstrates that tacrolimus 0.075% ointment may be effective for patients with steroid-induced rosacea, when combined with avoidance of topical steroid use, as well as avoidance of other agents known to aggravate rosacea (caffeine, spicy foods, alcohol, hot fluids, and fluoride).

PMID: 11369912 [PubMed - indexed for MEDLINE] More here: Journal Scan - Dermatology 2(7)

8) Botox experiences?...please report to the group...

9) Topical 0.5 % to 2.0 % Glycopyrrolate for Gustatory Flushing or only Gustatory Sweating?...please report to the group

10) New Photoderm Patients Page & Welcome to ESC Medical Systems

11) ETS Controversies & Lingering Questions Section coming soon, here are questions submitted to the Symposium in Finland

Abstracts from 4th International Symposium courtesy of Tom C.

12) Role of allergies in symptoms?, I'll defer to the experience of Suzi LeBaron on the Yahoo Rosacea group for consideration.

http://www.celiac.com - A very useful site on gluten intolerance.

13) Rosacea diet?

Mark has posted his diet in 2 parts in the group file area. The 2 links are
http://groups.yahoo.com/group/rosacea-support/files/My%20Diet.html
http://groups.yahoo.com/group/rosacea-support/files/My%20Diet-Part%202.html

14) Thermoregulation issues? - Do Rosaceans have an autonomic dysfunction, overactive SNS, etc..?

It might be a good idea for those with unresolved Rosacea/Heat Intolerance/FB/FF/HH & prospective ETS patients to get tested (even perhaps before, during & after treatments):

Autonomic Laboratory - Autonomic Testing Description at Universities or Mayo Clinic

Autonomic Reflex Tests

Alternative Med ANS testing info from ThriveOnline - may be a bit slow to load.

The Nervous System Chapter from Emory Univ via Medscape - Extensive descriptions & diagrams.

The Peripheral Nervous System - Very Interesting.  Worth a look.

15) Neuro-psychodermatology - How can Stress (an applied force or system of forces that tends to strain or deform a body) influence your skin & vice versa?

16) Recent post here on pain until section is up.  Another more recent post on pain & flushing here.  Much more on pain in # 4 Lessons Post here.

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17) Excessive blushing, flushing and sweating forums

http://www.bfsforum.com & http://groups.yahoo.com/group/sympathetics/ 

Sunless Tanning Site to help camouflage, Mystic Tan Salons - Safe Tans? http://melanotan.does.it/ - Board dedicated to formulating products to get a real sunless tan.

DO YOUR OWN RESEARCH AT:

Search the Web at http://www.google.com/ or http://www.metacrawler.com

or NewsGroups at http://www.deja.com 

Or PubMed/Medline at http://www.ncbi.nlm.nih.gov/entrez

or Medline at http://www.medscape.com

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