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Federal Route 54 runs southwest-northeast through a small section of west-central Illinois. It enters the state from Missouri through Pike County to terminate at Interstate 72/US36.

Intersections from SW to NE:

US54 enters Illinois near Louisiana, Missouri

IL96

IL106 joins from the west, west of Pittsfield

IL106 leaves to the east at Pittsfield

US54 ends at I-72/US36. North of I-72/US36, US54 becomes IL107.

Pittsfield is the only Illinois town that US54 passes through.

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