| | Jacksonville Jaguars New Orleans Saints | October 19, 8:00 PM at New Orleans, Louisiana |
| | Atlanta Falcons Tampa Bay Buccaneers | October 22, 1:00 PM at Tampa, Florida |
| | Buffalo Bills New England Patriots | October 22, 1:00 PM at Foxborough, Massachusetts |
| | Cleveland Browns Indianapolis Colts | October 22, 1:00 PM at Indianapolis, Indiana |
| | Detroit Lions Baltimore Ravens | October 22, 1:00 PM at Baltimore, Maryland |
| | Las Vegas Raiders Chicago Bears | October 22, 1:00 PM at Chicago, Illinois |
| | Washington Commanders New York Giants | October 22, 1:00 PM at East Rutherford, New Jersey |
| | Arizona Cardinals Seattle Seahawks | October 22, 4:00 PM at Seattle, Washington |
| | Green Bay Packers Denver Broncos | October 22, 4:00 PM at Denver, Colorado |
| | Los Angeles Chargers Kansas City Chiefs | October 22, 4:00 PM at Kansas City, Missouri |
| | Pittsburgh Steelers Los Angeles Rams | October 22, 4:00 PM at Inglewood, California |
| | Miami Dolphins Philadelphia Eagles | October 22, 8:00 PM at Philadelphia, Pennsylvania |
| | San Francisco 49ers Minnesota Vikings | October 23, 8:00 PM at Minneapolis, Minnesota |