Presented in credits order.
| John Cusack | Martin Q. Blank |
| Minnie Driver | Debi Newberry |
| Alan Arkin | Dr. Oatman |
| Dan Aykroyd | Grocer |
| Joan Cusack | Marcella |
| Hank Azaria | Steven Lardner |
| K. Todd Freeman | Kevin McCullers |
| Mitchell Ryan | Bart Newberry |
| Jeremy Piven | Paul Spericki |
| Michael Cudlitz | Bob Destepello |
| Benny Urquidez | Felix La PuBelle |
| Duffy Taylor | Ultimart Carl |
| Audrey Kissel | Arlene |
| Carlos Jacott | Ken McCullard |
| Brian Powell | Husky Man |
| Ann Cusack | Amy |
| D.V. DeVincentis | Dan Koretzky |
| Barbara Harris | Mary Blank |
| Wendy Thorlakson | Melanie the Waitress |
| Belita Moreno | Mrs. Kinetta |
| Pat O'Neill | Nathaniel |
| Jenna Elfman | Tanya |
| Steve Pink | Terry Rostand |
| K.K. Dodds | Tracy |
| Bill Cusack | Waiter |
| Traci Dority | Jenny Slater |
| Doug Dearth | Eckhart |
| Colby French | Bartender |
| Brent Armitage | Cosmo |
| Jackie Rubin | Marie |
| Sarah DeVincentis | Dr. Oatman's Patient |
| Eva Rodriguez | Nurse |
| David Barrett | Bicycle Messenger |
| Bobby Bass | Assassin #1 |
| Lance Gilbert | Assassin #2 |
| Pete Antico | Assassin #3 |
| Laurence Bilzerian | Assassin #4 |
