Magneto has lost the war against ordinary humans for which he sacrificed the well-being of his children. Now he is forced to watch his daughter Wanda, the Scarlet Witch, suffer a loss of control over both her powers and her grip on reality. Quicksilver, Wanda's brother Pietro, pleads with their estranged father to help her.

Mutant leader Charles Xavier, who is unable to help the Scarlet Witch, gathers the Avengers and the X-Men to decide how to proceed. The heroes are not convinced that killing Wanda is the only solution, so they travel to the mutant nation of Genosha to confront her, in the hope of discovering what it is that she wants.

When they get to the island, Wanda is missing, as are Magneto and Pietro.

Then the world burns to white...Reality as we knew it is gone...