ACT 1: The next morning, a group of students are visiting the museum, unaware but to one student that Spider-Man is laying underneath the thousands of spiders within the exhibition. As they walk away, Ezekiel emerges from the shadow, phone in hand: "I've found him. Get the helicopter Ready." he says.

ACT 2: The story switches to the West African country known as Ghana, where we are introduced to Kwaku Anansi, a man who used to live in that region centuries ago. It had been rumored that he sometimes looked like a wise old man whereas other times, it was said that he looked more like a spider traveling across the sunny African sky on strings of web. Having webbed his way across the entire land, from top to bottom, Kwaku had yearned to learn more, to see past he horizon, so he revolved to climb into the sky itself to meet with Nyame, the sky-god, to obtain knowledge of the entire mortal world and the world beyond. Nyame accepted to provide Kwaku with that infinite wisdom only if he agreed to meet his demands. Kwaku accepted. From that moment on, Kwaku passed forever from the eyes of the waking world but his knowledge was passed to his children and his children's children and so on. Kwaku who was both spider and man became even more the spider in his service to the sky-god, both father and mother to the spiders of the world. Only once was the power of the spiders given freely as a direct product of science: when Peter became Spider-Man…Peter awakes in a small room, laying in bed, his mask and the upper part of his costume removed. Ezekiel is at his side, sitting on a chair. They are in Ghana, Africa.

ACT 3: Ezekiel leads Peter down into ruins located inside a huge tent. A gigantic spider symbol lays at the ground of the ruins, similar to five others around the world, one of which Ezekiel obtained his power from. Ezekiel tells Peter that the incident that gave him his abilities may not have been so incidental after all, that perhaps mystical forces were at play when he was bitten by the radioactive spider. Peter asks Ezekiel if the ruins will protect him from Shathra. Ezekiel lets him know that Shathra will find him faster now that she could on her own, but that she will arrive worried since the ruins are home to the spider. As the conversation ends, Ezekiel turns around: "She's coming." he says. He leaves Peter and goes down deeper underneath the ruins. As he walks down the stairs, he reaches an alcove in the wall in which a knife is sitting. Ezekiel grabs the knife and slices his hand open; blood pouring onto the ground. A small spider is seen walking in the blood.

ACT 4: Peter dons his costume and awaits his opponent. She slashes through the tent and shoots another paralyzing sting at him. He avoids the dart and attacks her. A great battle follows over several pages (courtesy of Romita Jr. once again). Spider-Man gives her all he's got and as he gets the upper hand on her, millions of small spiders suddenly emerge from the ground below and envelop her body completely, sending her in a complete frenzy. The spiders spin their webs around her limp body and the entire web cocoon falls down into the hole at the center of the gigantic spider symbol, apparently killing off Shathra at the same time.

ACT 5: The story switches back to Los Angeles, at Mary Jane's apartment. She is packing up her bags, a first class airplane ticket to New York is lying on the bed beside them.