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PUBLICATIONS

Scholer-Dahirel A, Schlabach M, Loo A, et al. (2011) Maintenance of APC-mutant colorectal cancer is dependent on Wnt/β-catenin signaling. PNAS, submitted.

Waters NJ, Rajlic IL, Loo A, et al. (2011) Pharmacokinetic-pharmacodynamic modeling enables preclinical validation of the PKC inhibitor, sotrastaurin, in xenograft models of diffuse large B-cell lymphoma. JPET, submitted.

Naylor TL, Tang H, Ratsch BA, Enns A, Loo A, et al (2011) Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas. Cancer Res 71(7):2643-53. PMID:21324920

Jagani Z, Wiederschain D, Loo A, et al (2010) Bmi-1 is Important for the Growth of Multiple Myeloma Cells and Suppresses Apoptosis via the Regulation of the Pro-Apoptotic Gene Bim. Cancer Res 70(13):5528-38. PMID:20530672

Beroukhim R, Mermel C, Porter D, et al (2009) The landscape of somatic copy number alteration across human cancer types. Nature 463(7283):899-905. PMID:20164920

Wee S, Jagani Z, Xiang K, Loo A et al (2009) PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers. Cancer Research 69:4286-93. PMID:19401449

Wiederschain D, Wee S, Chen L, Loo A et al (2009) Single-vector inducible lentiviral RNAi system for oncology target validation. Cell Cycle 8:498-504. PMID:19177017

Wee S, Wiederschain D, Maira S, Loo A et al (2008) PTEN-deficient cancers depend on PIK3CB. PNAS 105:13057-13062. PMID:18755892

Parker MF, Bronson JJ, Barten DM, Corsa JA, Du W, Felsenstein KM, Guss VL, Izzarelli D, Loo A, et al (2007) Amino-caprolactam derivatives as gamma-secretase inhibitors. Bioorg Med Chem Lett 17(21):5790-5 PMID:17869509

Prasad CV, Zheng M, Vig S, Bergstrom C, Smith DW, Gao Q, Yeola S, Polson CT, Corsa JA, Guss VL, Loo A, et al (2007) Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Alzheimer's disease. Bioorg Med Chem Lett 17(14):4006-11 PMID:17502137

Barten DM, VL Guss, JA Corsa, A Loo et al (2005) Dynamics of beta-Amyloid Reductions in Brain, Cerebrospinal Fluid and Plasma of beta-Amyloid Precursor Protein Transgenic Mice Treated with a gamma-Secretase Inhibitor. J Pharmacol Exp Ther. 312(2):635-43. PMID:15452193

Prasad CV, Vig S, Smith DW, Gao Q, Polson CT, Corsa JA, Guss VL, Loo A et al (2004) 2,3-Benzodiazepin-1,4-diones as peptidomimetic inhibitors of gamma-secretase. Bioorg Med Chem Lett. 14(13):3535-8. PMID:15177468

Nandi J, A Loo, S.Kim & R.A.Levine (1999) Expression and characterization of protein kinase C in isolated rabbit parietal cells. Int. J. Molecular Medicine 3(5):521-526. PMID:10202185

Sukumar P, A Loo, R Aldophe, J Nandi, A Oler & RA Levine (1999) Dietary nucleotides augment dextran sulfate sodium induced distal colitis in rats. J. Nutrition. 129:1377-1381. PMID:10395601

Reedy DW, A Loo & RA Levine (1998) AST/ALT ratio >=1 is not diagnostic of cirrhosis in patients with chronic hepatitis C. Dig. Dis. Sci. 43(9):2156-2159. PMID:9753286

Sukumar P , A Loo, E Magur, J Nandi, A Oler & RA Levine (1997) Dietary supplementation of nucleotides and arginine promotes healing of small bowel ulcers in experimental enterocolitis. Dig. Dis. Sci. 42:1530-1536. PMID:9246059

Nandi J, A Loo & RA Levine (1997) An endogenous activator protein of H+,K+ ATPase regulates acid secretion in isolated rabbit gastric glands. Gastroenterology 112(4):A231.

Reedy DW, J Nandi, A Loo, H Mahoney & RA Levine (1996) Parallelism of serum HCV RNA and ALT levels during breakthrough and/or relapse in patients treated with alpha interferon for chronic hepatitis C. Hepatology 24(4)Pt 2:565A.

Loo A, S Youngentob, P Kent & J Schwob (1996) The aging olfactory epithelium: neurogenesis, response to damage, and odorant induced activity. Int. J. Dev. Neurosci. 14(7/8):881-900. PMID:9010732


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