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BIO-TECH RESEARCH

CLINICAL TRIALS RESEARCH LINK

04-10-01

Nasdaq STEM---

Researchers Turn Special Fat Cells to Muscle, Bone, Cartilage

Washington, April 10 (Bloomberg) -- Those unwanted extra pounds may help open up the field of regenerative medicine, according to researchers who located a special fat cell that they said could become bone, cartilage and muscle.

Using fat gathered through liposuction procedures, researchers identified and isolated adult ``stem cells,'' and were able to guide their development so that the fat cells grew into a variety of human tissues in the laboratory.

The finding could pave the way for scientists to develop regenerative treatments to help heal broken bones, repair congenital bone defects, and reverse the course of osteoporosis, according to Pat Zuck, a University of California Los Angeles researcher who wrote the study, which appears today in the journal Tissue Engineering.

``Sometimes things seem to be too good to be true, but this may actually be as good as it seems,'' Zuck said. ``This is standard liposuction tissue that comes out of the operating room.''

The team said the findings were particularly important because fat offers an inexpensive, plentiful and easy-to-access supply of cells for research in a field that may hold potential for treating conditions like Parkinson's disease, Alzheimer's disease and diabetes.

Companies including StemCells Inc., Geron Corp., and Curis Inc. are working to develop treatments that make use of stem cells, which appear able to respond to the needs of the body to become nearly any kind of tissue.

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04-09-01

Symbol Name Current Change % Change Volume

LANN News Lannett Company Inc. 0.850 +0.225 +36.00% 5K

HMGN News Hemagen Diagnostics, Inc. 0.930 +0.240 +34.78% 25.4K

ALLP News Alliance Pharmaceutical Corp. 3.480 +0.850 +32.32% 214.8K

POLXF News Polydex Pharmaceuticals Ltd. 4.000 +0.870 +27.80% 100

CKPT News Checkpoint Genetics Pharmaceuticals Inc. 5.000 +1.000 +25.00% 6.6K

OSTX News Ostex International, Inc. 1.320 +0.260 +24.53% 15.1K

HMSR News HemaSure, Inc. 0.370 +0.070 +23.33% 5K

FSFI News First Scientific Inc. 0.160 +0.030 +23.08% 85.2K

APPI News Advanced Plant Pharmaceuticals, Inc. 0.049 +0.009 +22.50% 776.9K

IGEN News IGENr International Inc. 20.500 +3.750 +22.39% 1.23M

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04-04-01

Symbol Name Current Change % Change Volume

INIS News International Isotopes Inc. 0.125 +0.063 +100.00% 1000

RADX News Radiance Medical Systems, Inc. 4.250 +1.188 +38.78% 129.7K

BZET News Biofield Corp. 0.340 +0.080 +30.77% 14.4K

CVGR News Covalent Group, Inc. 2.125 +0.375 +21.43% 138.4K

ITMN News Intermune Pharmaceuticals Inc. 19.313 +3.375 +21.18% 903.7K

ENDO News ENDOcare, Inc. 6.188 +1.063 +20.73% 258.1K

CARN News Carrington Laboratories 1.188 +0.188 +18.75% 33K

MCHM News MacroChem Corporation 4.730 +0.710 +17.66% 516.7K

PHYX News Physiometrix, Inc. 5.000 +0.750 +17.65% 389.4K

CHAI News Life Medical Sciences Inc. 0.140 +0.020 +16.67% 18.5K

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04-02-01

Symbol Name Current Change % Change Volume

UNVC News UNIVEC Corporation 0.200 +0.060 +42.86% 5K

CKPT News Checkpoint Genetics Pharmaceuticals Inc. 6.500 +1.400 +27.45% 200

OXIS News Oxis International, Inc. 0.344 +0.063 +22.22% 17.8K

SNUS News SONUS Pharmaceuticals, Inc. 1.219 +0.219 +21.88% 19.8K

PRXX News Praxis Pharmaceuticals Inc. 0.170 +0.030 +21.43% 11.5K

BIORY News Biora AB 2.625 +0.438 +20.00% 1000

ISTA News Ista Pharmaceuticals Inc. 4.000 +0.625 +18.52% 154.3K

MS News Milestone Scientific, Inc. 1.000 +0.150 +17.65% 23.1K

BRLI News Bio-Reference Laboratories 1.313 +0.188 +16.67% 13.7K

ALTH News Allos Therapeutics 6.750 +0.938 +16.13% 110.1K

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03-29-01

Symbol Name Current Change % Change Volume

OXIS News Oxis International, Inc. 0.313 +0.094 +42.89% 177.5K

AMEV News Applied Molecular Evolution Inc. 9.000 +2.250 +33.33% 184.3K

ARDM News Aradigm 5.625 +1.344 +31.39% 692.8K

PPTI News Protein Polymer Technologies, Inc. 0.937 +0.217 +30.14% 76K

CVM News CEL-SCI 2.000 +0.460 +29.87% 66.5K

BTRN News BioTransplant Incorporated 4.875 +1.094 +28.93% 107K

ACEL News Alfacell 1.000 +0.219 +28.04% 199K

ESPR News Esperion Therapeutics 5.375 +1.094 +25.55% 287.5K

ZKEM News Xechem International 0.035 +0.007 +25.00% 924.4K

BNRX News Bionutrics 0.875 +0.156 +21.75% 1.9K

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03-27-01

Symbol Name Current Change % Change Volume

PHST News Pharsight Corp. 3.875 +1.125 +40.91% 36.5K

CVM News CEL-SCI 2.000 +0.550 +37.93% 138.7K

EDEN News EDEN Bioscience 15.250 +4.188 +37.85% 1.27M

FSFI News First Scientific Inc. 0.160 +0.040 +33.33% 140.3K

ARIA News Ariad Pharmaceuticals, Inc. 4.938 +1.219 +32.77% 358.7K

HEB News Hemispherx Biopharma Inc. 4.500 +1.110 +32.74% 100.1K

LXXN News Lexon 0.437 +0.107 +32.42% 22K

UGNE News Unigene 0.550 +0.130 +30.95% 1.29M

RGEN News Repligen Corporation 3.000 +0.688 +29.73% 658.7K

TRGNY News TRANSGENE S.A. 4.500 +1.000 +28.57% 9K

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03-26-01

Symbol Name Current Change % Change Volume

EECN News Ecogen Inc. 0.200 +0.070 +53.85% 70.6K

HGAT News HealthGate Data Corp. 0.313 +0.094 +42.89% 21.4K

PLMD News PolyMedica Corporation 24.250 +7.250 +42.65% 10.21M

AXYX News Axonyx Inc. 4.719 +1.094 +30.17% 103.2K

GISH News Gish Biomedical 1.625 +0.375 +30.00% 2.7K

BNRX News Bionutrics 0.688 +0.156 +29.42% 1.1K

AZA News ALZA Corporation 38.750 +8.700 +28.95% 21.85M

MABA News American Biogenetic Sciences, Inc. 0.750 +0.156 +26.33% 198.2K

BASEA News Base Ten Systems Inc. 0.063 +0.013 +26.00% 400

DRRX News DURECT Corporation 6.125 +1.250 +25.64% 187.6K

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