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What is Polycythemia Rubra Vera (PRV)?

      There are six diseases included in the group of myeloproliferative disorders and this group includes chronic myelogenous leukemia (CML), polycythemia rubra vera (PRV), chronic idiopathic myelofibrosis, essential thrombocythemia (ET), chronic neutrophilic leukemia, and chronic eosinophilic leukemia. This group is characterized by production of too many of certain types of blood cells are made in the bone marrow. There is a great deal of overlap in the features of various myeloproliferative disorders and may transform from one from to another. Polycythemia rubra vera is characterized by the production of mature red cells leading to high levels of hemoglobin. This would lead to increase blood volume and viscosity, which can lead to various complications. Complications may vary from person to person and may include development of blood clots or bleeding. Apart from increase in the red cells Polycythemia rubra vera is associated with increase in platelet count and white cell counts. PRV is a relatively rare disorder, and is estimated to occur, in approximately 1 in 100,000 individuals. Polycythemia Vera is primarily affects middle-aged or elderly people. The highest incidence of Polycythemia rubra vera occurs in patients who are in the 51-75 age group.

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