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How is Polycythemia Rubra Vera Diagnosed?

      Based on various symptoms and signs your hematologist may make a diagnosis of polycythemia rubra vera. There are diagnostic criteria set by Polycythemia Vera Study Group to make a diagnosis of this disease. This includes some findings in the physical examination and some findings form laboratory tests. Some conditions associated with decrease in the oxygenation of blood may be associated with increase in the red blood cells, and this is the most important challenge for the hematologist to undertake when making the diagnosis of polycythemia rubra vera. Measurement of red cell volume, level of increase in the platelet count and white cell count, level of a erythropoietin and presence of enlargement of spleen, all may help the hematologist to make a differential diagnosis in this situation. These physical and laboratory findings are critical in the diagnosis of polycythemia rubra vera. Increased leukocyte alkaline phosphate activity, or increased vitamin B12 levels are often helpful in making the diagnosis.

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