Second Round
Zamalek-3/1-Rayon Sports (Rwanda)  
Date: 15 Mar 2015
Scorers: Ahmed Eid Abdel Malek 6" Pen, 45" / Ahmed Tawfik 37"
Line-Up: Ahmed El-Shennawi / Hazem Emam / Ali Gabr / Ahmed Dewidar / Hamada Tolba / Ibrahim Salah / Ahmed Tawfik / Maarouf Youssef (Mohamed Koffi) / Ayman Hefny / Ahmed Eid Abdel Malek (Basem Morsi) / Khaled Qamar (Ahmed Ali)

Rayon Sports (Rwanda)-0/3-Zamalek  
Date: 5 Apr 2015
Scorers: Ahmed Eid Abdel Malek 33" / Ali Gabr 53" / Ibrahim Salah 56"
Line-Up: Ahmed El-Shennawi (Mahmoud Abdel Rehim "Gennesh") / Hazem Emam / Ali Gabr / Ahmed Dewidar / Hamada Tolba / Ibrahim Salah / Omar Gaber (Ahmed Tawfik) / Maarouf Youssef / Ayman Hefny / Ahmed Eid Abdel Malek  / Basem Morsi (Khaled Qamar)  

Third Round 
Zamalek-0/0-Fath Union Sport de Rabat "FUS Rabat" (Morocco)
Date: 19 Apr 2015
Line-Up: Ahmed El-Shennawi / Hazem Emam / Islam Gamal / Mohamed Koffi / Hamada Tolba / Ibrahim Salah / Omar Gaber (Khaled Qamar) / Maarouf Youssef (Ahmed Tawfik) / Ayman Hefny / Ahmed Eid Abdel Malek  (Basem Morsi)  / Ahmed Ali  

Fath Union Sport de Rabat "FUS Rabat" (Morocco)-2/3-Zamalek  
Date: 4 May 2015
Scorers: Basem Morsi 15" / Omar Gaber 84" / Hazem Emam 90+5"
Line-Up: Ahmed El-Shennawi / Omar Gaber / Ali Gabr / Mohamed Koffi / Hamada Tolba / Ahmed Samir (Ahmed Ali) / Ibrahim Salah / Ahmed Tawfik (Hazem Emam) / Maarouf Youssef / Ahmed Eid Abdel Malek (Moustafa Fathi) / Basem Morsi  

Added Round of 16 vs Losers of Champion League 
SM Sanga Balende (RD Congo) 1/0-Zamalek  
Date: 17 May 2015
Line-Up: Ahmed El-Shennawi / Hazem Emam / Ali Gabr / Mohamed Koffi / Hamada Tolba / Ahmed Tawfik (Omar Gaber) / Ibrahim Salah / Maarouf Youssef / Moustafa Fathi (Ahmed Eid Abdel Malek) / Ahmed Ali (Ayman Hefny) / Basem Morsi

Zamalek 3/1-SM Sanga Balende (RD Congo)  
Date: 7 June 2015
Scorers: Ayman Hefny 48" / Omar Gaber 64" / Khaled Qamar 78" 
Line-Up: Ahmed El-Shennawi / Hazem Emam / Ali Gabr / Mohamed Koffi / Hamada Tolba / Ahmed Tawfik (Moustafa Fathi) / Ibrahim Salah / Omar Gaber / Ayman Hefny / Ahmed Eid Abdel Malek (Khaled Qamar) / Basem Morsi (Tarek Hamed)

Quarter Final - Group B 
Zamalek-1/0-CS Sfaxien (Tunisia)
Date: 27 June 2015 
Scorer: Abdoulaye Cissé 90"
Line-Up: Ahmed El-Shennawi / Hazem Emam / Ali Gabr / Mohamed Koffi / Hamada Tolba (Abdoulaye Cissé) / Omar Gaber / Ahmed Tawfik (Youssef Ibrahim "Obama") / Ibrahim Salah / Ayman Hefny / Moustafa Fathi / Khaled Qamar (Ahmed Ali) 

Orlando Pirates (South Africa)-1/2-Zamalek
Date: 11 July 2015 
Scorers: Maarouf Youssef 72" / Moustafa Fathi 83"
Line-Up: Ahmed El-Shennawi / Hamada Tolba / Ali Gabr / Mohamed Koffi / Ahmed Samir / Ahmed Tawfik / Ibrahim Salah / Maarouf Youssef / Ayman Hefny (Tarek Hamed) / Ahmed Eid Abdel Malek (Moustafa Fathi) / Basem Morsi (Khaled Qamar)  

Zamalek-2/0-AC Leopards (Congo)
Date: 26 July 2015 
Scorers: Basem Morsi 2" / Ayman Hefny 36" Pen
Line-Up: Ahmed El-Shennawi / Hazem Emam / Ali Gabr / Mohamed Koffi / Hamada Tolba / Maarouf Youssef (Tarek Hamed) / Ahmed Tawfik / Ibrahim Salah / Ayman Hefny (Moustafa Fathi) / Basem Morsi / Khaled Qamar (Ahmed Samir) 

AC Leopards (Congo)-1/0-Zamalek
Date: 9 August 2015 
Line-Up: Mohamed Abou Gabal / Hazem Emam / Ali Gabr / Mohamed Koffi / Hamada Tolba (Mohamed Salem) / Omar Gaber (Mohamed Ibrahim) / Tarek Hamed / Maarouf Youssef / Mahmoud Abdel Monem "Kahraba" / Moustafa Fathi (Mohamed Adel Gomaa) / Basem Morsi

CS Sfaxien (Tunisia)-1/3-Zamalek
Date: 23 Aug 2015 
Scorers: Mahmoud Abdel Monem "Kahraba" 54" / Ahmed Hammoudi 80", 90+3" Pen [Kahraba missed a penalty for Zamalek in 72nd min]
Line-Up: Ahmed El-Shennawi / Ahmed Tawfik / Ali Gabr / Ahmed Dewidar / Hamada Tolba / Tarek Hamed / Ibrahim Salah / Maarouf Youssef (Ahmed Hassan Mekki) / Mohamed Ibrahim (Mohamed Salem) / Mahmoud Abdel Monem "Kahraba" / Basem Morsi (Ahmed Hammoudi) 

Zamalek-4/1-Orlando Pirates (South Africa)
Date: 13 Sep 2015 
Scorers: Ahmed Tawfik 14" / Ahmed Hassan Mekki 37" / Moustafa Fathi 62" / Mahmoud Abdel Monem "Kahraba" 67"
Line-Up: Mahmoud Abdel Rehim "Gennesh" / Ahmed Tawfik / Ali Gabr / Mohamed Koffi / Hamada Tolba / Omar Gaber (Ayman Hefny) / Tarek Hamed / Maarouf Youssef / Mohamed Ibrahim (Moustafa Fathi) / Mahmoud Abdel Monem "Kahraba" (Ahmed Hammoudi) / Ahmed Hassan Mekki    

Semi Final 
Etoile du Sahel "Al-Najm Al-Sahily" (Tunisia)-5/1-Zamalek
Date: 27 Sep 2015 
Scorer: Ayman Hefny 25"
Line-Up: Ahmed El-Shennawi / Hazem Emam / Ali Gabr / Mohamed Koffi / Hamada Tolba (Mohamed Adel Gomaa) / Omar Gaber / Tarek Hamed / Maarouf Youssef (Moustafa Fathi) / Ayman Hefny (Ahmed Hammoudi) / Mahmoud Abdel Monem "Kahraba" / Basem Morsi  

Zamalek-3/0-Etoile du Sahel "Al-Najm Al-Sahily" (Tunisia)
Date: 3 Oct 2015 
Scorers: Mahmoud Abdel Monem "Kahraba" 12", 55" Pen / Own Goal "Ghazi Abdel Razek" 70"
Line-Up: AAhmed El-Shennawi / Hazem Emam / Ahmed Dewidar / Ali Gabr 5" / Mohamed Adel Gomaa (Moustafa Fathi 67") / Tarek Hamed / Omar Gaber / Ahmed Hammoudi (Mohamed Koffi 20") / Ayman Hefny (Ahmed Hassan Mekki 57") / Mahmoud Abdel Momem "Kahraba" / Basem Morsi